化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → (R)-3-amino-1-carbomethoxymethyl-3,4-dihydrocarbostyril hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (R)-3-t-butyloxycarbonylamino-1-carbomethoxymethyl-3,4-dihydrocarbostyril | HCID 69194872 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | (R)-3-amino-1-carbomethoxymethyl-3,4-dihydrocarbostyril hydrochloride | HCID 69197166 | — |
反応手順
(R)-3-t-butyloxycarbonylamino-1-carbomethoxymethyl-3,4-dihydrocarbostyril (20 mg) was dissolved in 4 M hydrogen chloride in 1,4-dioxane solution (5 mL) at room temperature. After 1 h the solvent was evaporated under vacuum, and the residue was twice taken up in toluene (10 mL) and evaporated under vacuum to provide (R)-3-amino-1-carbomethoxymethyl-3,4-dihydrocarbostyril hydrochloride, a white solid (21 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098235B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-78cfe89bac18470c801689497e4e731f |
| 出典メモ | uspto-grants-2006_08 |