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3-[(4-Hydroxymethyl-phenyl)-methoxy-methyl]-benzonitrile → 3-{[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-methoxy-methyl}-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-[(4-Hydroxymethyl-phenyl)-methoxy-methyl]-benzonitrile | HCID 57438353 | — |
| 反応物 | 3-[[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-(tetrahydro-pyran-2-yloxy)-methyl]-benzonitrile | HCID 66699604 | — |
| 生成物 | 3-{[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-methoxy-methyl}-benzonitrile | HCID 66699558 | — |
反応手順
The title compound is prepared in a similar manner to 3-[[4-(4-acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-(tetrahydro-pyran-2-yloxy)-methyl]-benzonitrile employing 3-[(4-Hydroxymethyl-phenyl)-methoxy-methyl]-benzonitrile to afford 248 mg, 78%, as a colorless oil. LCMS M+1 430.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07816523B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-e86ae1cbac5145a68753c6c04e78cfc7 |
| 出典メモ | uspto-grants-2010_10 |