化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 4-Bromo-2-(hydroxymethyl)-6-methoxyphenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 5-Bromo-2-hydroxy-3-methoxybenzaldehyde | HCID 262238 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Bromo-2-(hydroxymethyl)-6-methoxyphenol | HCID 894092 | 99.1% |
反応手順
To a solution of 50 g of 5-bromo-2-hydroxy-3-methoxybenzaldehyde in 200 ml of an ethanol:THF=1:1 mixed solvent there was added 16.4 g of sodium borohydride while cooling on ice. After stirring at room temperature for 2 hours, 1N hydrochloric acid was added to the reaction mixture while cooling on ice. The organic layer was washed with ethyl acetate and dried over anhydrous magnesium sulfate. The desiccating agent was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (50 g) as a crude product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07816522B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-f70b09cfff0e422789fe0e0e9bd0e158 |
| 出典メモ | uspto-grants-2010_10 |