関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetraglyme | HCID 8925 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 2-Propanol, 1,1'-(methylimino)bis- | HCID 95655 | — |
| 触媒 | Ruthenium trichloride hydrate | HCID 6093376 | — |
| 生成物 | HCID 19862111 | HCID 19862111 | 65% |
反応手順
A mixture of N-methyl-bis-(2-hydroxypropyl)amine (75g, 0.51 mol), trans-4-phenyl-3-buten-2-one (75g, 10.51 mol), ruthenium trichloride hydrate (0.626g 12.3 mmole), triphenylphosphine (2.0g 17.6 mmole), and tetraglyme (30g) was added to a 250-ml 3-neck round bottom flask connected with a fractional distillation set and a thermometer. The reaction was heated to 180° C. under nitrogen and the products were distilled out through the distillation set. The products (organic layer) were then fractionally distilled again to obtain a 65% yield of 3,4-dihydro-2,4,6-trimethyl-2H-1,4-oxazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04910303 |
|---|
| 出典データセット | uspto-grants-1990_03 |
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| ORD ID | ord-9f0269cca29547f29e294bb170fed892 |
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| 出典メモ | uspto-grants-1990_03 |
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