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Tosylmethyl isocyanide → 5-[5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)-phenyl]oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tosylmethyl isocyanide | HCID 161915 | — |
| 反応物 | 5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde | HCID 86070969 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-[5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)-phenyl]oxazole | HCID 68681178 | — |
反応手順
1 g of 5-bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde and 0.54 g of p-toluenesulfonylmethyl isocyanide are dissolved in 40 ml of methanol, 0.38 g of o-potassiumcarbonate is added in portions, and the reaction mixture is heated to reflux for 18 h. The solvent is then distilled off, and the crude product is purified by silica gel chromatography (ethyl acetate/heptane).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727989B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-552dac4e3cd44625bf490bacd309abfc |
| 出典メモ | uspto-grants-2010_06 |