関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-Amino-6-chloropyrimidine | HCID 238012 | — |
| 反応物 | 4-(2-Piperazin-1-yl-ethyl)-morpholine | HCID 2734640 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 6-[4-(2-Morpholin-4-ylethyl)piperazin-1-yl]pyrimidin-4-amine | HCID 21934600 | — |
反応手順
6-chloropyrimidin-4-amine 7-2 (3.09 g, 23.9 mmol) and diisopropylethylamine (3.08 g, 23.9 mmol) were suspended in n-butanol and then 4-(2-piperazin-1-ylethyl)morpholine 7-3 (4.75 g, 23.9 mmol) was added. The reaction was stirred at 125° C. for 18 hours and then the product was filtered off, washed with n-butanol and ethyl ether and then air dried. Hi-Res MS: calc: 293.2084 found: 293.2078. 1H-NMR (DMSO): 7.94 ppm (s, 1H); 6.18 ppm (s, 2H); 5.57 ppm (s, 1H); 3.56 ppm (m, 6H); 3.39 ppm (m, 8H); 2.47 ppm (m, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07115597B2 |
|---|
| 出典データセット | uspto-grants-2006_10 |
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| ORD ID | ord-0481e34e5d6b4bfa9e73dc34b97ef510 |
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| 出典メモ | uspto-grants-2006_10 |
|---|
