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N,N-Dimethylaniline → 6-Chloro-2[[4-(dimethylamino)phenyl]amino]3-nitrobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylaniline | HCID 949 | — |
| 反応物 | N,N-dimethyl-p-phenylenediamine | HCID 7472 | — |
| 反応物 | 2,6-Dichloro-3-nitrobenzoic acid | HCID 350623 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-Chloro-2[[4-(dimethylamino)phenyl]amino]3-nitrobenzoic acid | HCID 13588348 | — |
反応手順
A mixture of 41.0 g of N,N-dimethyl-p-phenylenediamine, 100 ml of N,N-dimethylaniline, and 23.6 g of 2,6-dichloro-3-nitrobenzoic acid was heated for seven hours on a steam bath. The resulting cake was suspended in dichloromethane, filtered, and the solid washed with water. Recrystallization from DMF-ethanol provided 6-chloro-2[[4-(dimethylamino)phenyl]amino]-3-nitrobenzoic acid, mp 222°-223° C. (dec).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04626540 |
| 出典データセット | uspto-grants-1986_12 |
| ORD ID | ord-be0cc871550e43d7b1fe5ba975f8ad50 |
| 出典メモ | uspto-grants-1986_12 |