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Hydrochloric Acid → 2-Benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2,3-Dichloroanisole | HCID 16126 | — |
| 反応物 | 2-Benzofurancarbonyl chloride | HCID 38949 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone | HCID 54547284 | 76.1% |
反応手順
14 g (0.1 mole) of aluminium chloride are introduced little by little in a solution of 16 g (0.09 mole) of 2,3-dichloro-anisol and 16 g (0.09 mole) of 2-benzofurancarboxylic acid chloride in 200 ml of methylene chloride the mixture is taken up to reflux for 4 hours, then poured on crushed ice (300 g) and concentrated hydrochloric acid (10 ml); the precipitate is filtered off, washed with an aqueous solution of sodium hydroxide (10 N), then with water and dried. 22 g of 2-benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone are obtained. Melting point 148° C. after crystallization from ethylacetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04255585 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-45d108e2ff734fdfbc1b4d48fc16e452 |
| 出典メモ | uspto-grants-1981_03 |