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5-Bromomethyl-2-furancarboxylic acid ethyl ester → (+/-)-5-[[3,4-Dihydro-5-{1,2,8-trimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Bromomethyl-2-furancarboxylic acid ethyl ester | HCID 13789529 | — |
| 反応物 | (+/-)-5-[1,2,8-Trimethyl-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedione | HCID 22117215 | — |
| 生成物 | (+/-)-5-[[3,4-Dihydro-5-{1,2,8-trimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester | HCID 131722231 | — |
反応手順
The subtitle compound was prepared from the product of step (v) (0.95 g) and 5-bromomethyl-2-furancarboxylic acid ethyl ester (J. Chem. Soc. Perkin Trans. 1, 1981, 1125, Bull. Chem. Soc. Jpn. 1987, 60, 1807)(0.64 g) according to the method of example 1 step (iv). Purification was by chromatography eluting with 20% ethyl acetate in toluene. Yield 1.02 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06162808 |
| 出典データセット | uspto-grants-2000_12 |
| ORD ID | ord-965eb5b2f5714489bb2ddb2ab8110335 |
| 出典メモ | uspto-grants-2000_12 |