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5-Chloro-2-methylphenyl isothiocyanate → 1-(5-Chloro-2-methyl-phenyl)-3-(2-methyl-benzothiazol-5-yl)-thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Chloro-2-methylphenyl isothiocyanate | HCID 29519 | — |
| 反応物 | 5-Benzothiazolamine, 2-methyl- | HCID 36229 | — |
| 生成物 | 1-(5-Chloro-2-methyl-phenyl)-3-(2-methyl-benzothiazol-5-yl)-thiourea | HCID 10291386 | 29.3% |
反応手順
Prepared using Method A from 4.5 g (24.5 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 4.02 g (24.5 mmol) of 5-amino-2-methylbenzothiazole to give 6.0 g of crude material. Soxhlet extraction with EtOAc gave 2.5 g of pure title compound as a tan solid (29% yield, m.p. 173-174° C. ).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06455566B1 |
| 出典データセット | uspto-grants-2002_09 |
| ORD ID | ord-17ece07f429645d68db02adf78e1502e |
| 出典メモ | uspto-grants-2002_09 |