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Methanol → Methyl 2-methyl-3-nitrobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-Methyl-3-nitrobenzoic acid | HCID 16096 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | Methyl 2-methyl-3-nitrobenzoate | HCID 601165 | — |
反応手順
To 2-methyl-3-nitrobenzoic acid (10.0 g) is added methanol (100 ml) and thereto thionyl chloride (8 ml) is added dropwise at room temperature. After reflux for 2 hours, the reaction mixture is poured into ice-water and extracted with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-nitrobenzoate (10.8 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723648 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-c6d1437bef5145cca37826ac5ae090f0 |
| 出典メモ | uspto-grants-1998_03 |