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(2-Methoxyethyl)(methyl)amine → 5-[(2-Methoxy-ethyl)-methyl-amino]-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Methoxyethyl)(methyl)amine | HCID 300977 | — |
| 反応物 | 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013543 | — |
| 生成物 | 5-[(2-Methoxy-ethyl)-methyl-amino]-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25014251 | — |
反応手順
Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and (2-methoxy-ethyl)-methyl-amine (276 mg; 3.1 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 5-[(2-methoxy-ethyl)-methyl-amino]-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (61 mg, 59%) as an off-white powder. ES-HRMS m/e calcd for C19H31N4O2 (M+H+) 347.2442, found 347.2438.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728029B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-9ce1be243a884eb6b4e2074c4a2c34e8 |
| 出典メモ | uspto-grants-2010_06 |