6-Chlorotryptophan → 6-Chloro-N-formyl-L-tryptophan

HRID 1288448

反応式

HRID 1288448 の反応式
[CH:1]1[C:6]([Cl:7])=[CH:5][C:4]2[NH:8][CH:9]=[C:10]([CH2:11][CH:12]([NH2:16])[C:13]([OH:15])=[O:14])[C:3]=2[CH:2]=1.[CH:17](OC(=O)C)=[O:18]>>[CH:17]([NH:16][C@H:12]([C:13]([OH:15])=[O:14])[CH2:11][C:10]1[C:3]2[C:4](=[CH:5][C:6]([Cl:7])=[CH:1][CH:2]=2)[NH:8][CH:9]=1)=[O:18]

参加物

3

反応物 2

HCID 652596-ChlorotryptophanHCID 75269Acetic-formic anhydride

生成物 1

HCID 227910706-Chloro-N-formyl-L-tryptophan

実験手順

15 g(628 mM) of dl-6-chlorotryptophan was treated with 15 ml of acetic-formic anhydride. An exothermic reaction ensued, accompanied by solidification of the reaction slurry. Excess solvents were distilled off under vacuum and the resultant solids, after first leaching with dilute acid, were recrystallized from ethyl acetate to yield 12.45 g, 74%, of product, m.p. 181°-3° dec.

後処理

  1. customAn exothermic reaction
  2. distillationExcess solvents were distilled off under vacuum
  3. additionthe resultant solids, after first leaching with dilute acid
  4. customwere recrystallized from ethyl acetate
  5. customto yield 12.45 g, 74%

出典と根拠

ORDレコード
ord-ee27346fa3ca4db9a4bb3595ed96824f
出典データセット
uspto-grants-1976_10
特許番号
US03988349

関連ノート

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