Sodium Acetate → HCID 2910222、化合物

HRID 1289158

反応式

HRID 1289158 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=1.C([O-])(=O)C.[Na+].[S:24]1[CH2:30][C:28](=[O:29])[NH:27][C:25]1=[S:26]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[C:30]2[S:24][C:25](=[S:26])[NH:27][C:28]2=[O:29])=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 517045Sodium AcetateHCID 7354674-[(2-Chloro-6-fluorophenyl)methoxy]benzaldehydeHCID 1201546Rhodanine

生成物 1

HCID 2910222HCID 2910222、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Under a nitrogen atmosphere in a round bottom flask 4-[(2-chloro-6-fluorophenyl)methoxy]benzaldehyde (1.00 g, 3.78 mmol) was dissolved in acetic acid (19 ml). To this solution was added sodium acetate (1.08 g, 13.2 mmol) and then rhodanine (0.50 g, 3.75 mmol). The reaction mixture was then heated to reflux and maintained at this temeprature. The progress of the reaction was monitored by thin layer chromatography.

後処理

  1. temperatureThe reaction mixture was then heated
  2. temperatureto reflux
  3. temperaturemaintained at this temeprature

出典と根拠

ORDレコード
ord-093ea1f308e842fbb0137430c1943964
出典データセット
uspto-grants-1998_05
特許番号
US05747517

関連ノート

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