関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nimesulide | HCID 4495 | — |
| 反応物 | L-Lysine | HCID 5962 | — |
| 反応物 | beta-Cyclodextrin | HCID 444041 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 131720675 | HCID 131720675 | — |
反応手順
6.16 g of nimesulide (2×10-2 mole) are suspended in 200 ml of distilled water to which 6.56 g of L-lysine (4×10-2 mole) are added. The suspension is subjected to ultrasound for 5 minutes and then heated to 50° C. while violent agitation is maintained [Ultraturrax (registered mark)]. 26.3 g of β-CD·10H2O (2×10-2 mole) are dispersed in 200 ml of distilled water and heated to 50° C. The suspension of β-CD is added to the suspension of nimesulide and L-lysine. The agitation is continued for 15 minutes. An orangy solution is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05756546 |
|---|
| 出典データセット | uspto-grants-1998_05 |
|---|
| ORD ID | ord-bf87b3b19c2d42b5a53b4db108ba8a26 |
|---|
| 出典メモ | uspto-grants-1998_05 |
|---|
