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N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyvinyl)indol-1-yl]acetamide → N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-carboxy-1,3-butadienyl)indol-1-yl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyvinyl)indol-1-yl]acetamide | HCID 53736924 | — |
| 反応物 | N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxy-1,3-butadienyl)indol-1-yl]acetamide | HCID 53760680 | — |
| 反応物 | N-methyl-N-phenethyl-2-[1-benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-5-yl]acetamide | HCID 54354901 | — |
| 溶媒 | Acetone diethylether | HCID 21584533 | — |
| 生成物 | N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-carboxy-1,3-butadienyl)indol-1-yl]acetamide | HCID 53773500 | — |
反応手順
When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)-indol-1-yl]acetamide in the procedure of Example 23 is replaced with N-methyl-N-phenethyl-2-[1-benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-5-yl]acetamide then the product prepared is N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxy-1,3-butadienyl)indol-1-yl]acetamide. (solvent system (acetone/ether) m.p. 189°-190° C.)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05468898 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-bd45b897922d43b99bb2b0c2e44457dd |
| 出典メモ | uspto-grants-1995_11 |