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2-Aminothiazole → 5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 反応物 | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| 反応物 | 5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline | HCID 66998239 | — |
| 生成物 | N-[5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732911 | 69% |
| 生成物 | 5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene | HCID 66998975 | 539.3% |
反応手順
5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene (0.91 g, 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 5-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.66 g, 81%) following general procedure C. N-[5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (1309, 69%) was prepared from 5-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (126 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-867e53abdefb422fa7a085d135247e2b |
| 出典メモ | uspto-grants-2008_06 |