化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 3-(2-Methyl-allyloxy)-4-nitrotoluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Methallyl alcohol | HCID 10557 | — |
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | 4-Methyl-2-[(2-methylprop-2-en-1-yl)oxy]aniline | HCID 45091245 | — |
| 生成物 | HCID 59733018 | HCID 59733018 | 70% |
| 生成物 | 3-(2-Methyl-allyloxy)-4-nitrotoluene | HCID 60357844 | 75% |
反応手順
3-(2-Methyl-allyloxy)-4-nitrotoluene (0.78 g, 75%) was prepared from methallyl alcohol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(2-methyl-allyfoxy)aniline (0.47 g, 70%) following general procedure B. 1-[4-Methyl-2-(2-methyl-allyloxy)-phenyl]-3-thiazol-2-yl-urea (210 mg, 70%) was prepared from 4-methyl-2-(2-methyl-allyloxy)aniline (179 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-25995062b3c74c8cb170a8f08ba7950e |
| 出典メモ | uspto-grants-2008_06 |