関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Dibenzylamino-3-hydroxy-3-methyl-butyric acid ethyl ester | HCID 14824486 | — |
| 反応物 | Monosodium phosphate | HCID 23672064 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Dibenzylamino-3-hydroxy-3-methyl-butyric acid | HCID 21091403 | 53% |
反応手順
To 2.90 g (8.49 mmol) 2-dibenzylamino-3-hydroxy-3-methyl-butyric acid ethyl ester in 300 ml methanol were added 3.21 g (51.0 mmol) potassium hydroxide dissolved in 100 ml water. The mixture was stirred at 60° C. overnight. 500 ml saturated, aqueous sodium dihydrogenphosphate solution were added followed by extraction with ethyl acetate. Chromatography on silicagel with ethylacetate/heptan (50:50 to 100:0) yielded 1.41 g (53%) 2-dibenzylamino-3-hydroxy-3-methyl-butyric acid, MS m/e (%): 312.3 (M−H, 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07211573B2 |
|---|
| 出典データセット | uspto-grants-2007_05 |
|---|
| ORD ID | ord-3b4b424094904dfaac8d044f39af4af2 |
|---|
| 出典メモ | uspto-grants-2007_05 |
|---|
