化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylamine → 4-chloro-N,N-dimethylpyridine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-chloropyridine-2-carbonyl Chloride | HCID 11095146 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-chloro-N,N-dimethylpyridine-2-carboxamide | HCID 4962252 | — |
反応手順
A solution of 4-chloro-pyridine-2-carbonyl chloride (1 eq) in dichloromethane was cooled to 0° C., whereupon triethylamine (2 eq) was added followed by dimethylamine (2 eq, 2M solution in THF). The solution was allowed to warm to room temperature and let stir overnight. It was then washed with 1M NaOH. The separated organic layer is dried over MgSO4, filtered, and concentrated to yield the desired product. HPLC, 1.82 min; MS: MH+=185.6
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728010B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-af128e83c6f54f678c93c97cdc93799f |
| 出典メモ | uspto-grants-2010_06 |