化工社化工社 化学情報印刷レポート · 研究参考用
1,3-dimethyl-1H-indole-2-carbaldehyde → 4-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-dimethyl-1H-indole-2-carbaldehyde | HCID 2771468 | — |
| 反応物 | 4-fluoro-1-methyl-1H-indole-3-carbaldehyde | HCID 22138994 | — |
| 反応物 | Methyl 2-((5-bromopyridin-2-yl)amino)acetate | HCID 22139049 | — |
| 生成物 | 4-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole | HCID 22139151 | 77% |
反応手順
According to the procedure of Preparation 11 (c), except substituting 4-fluoro-1-methyl-1H-indole-3-carboxaldehyde (0.3 g, 1.69 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.2 g, 77%) was prepared as a viscous oil: MS (ES) m/e 193 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07879872B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-77306dd59f2b43fb918e6aa3a81063ba |
| 出典メモ | uspto-grants-2011_02 |