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4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride → 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyridin-2-ylamino]phenyl}benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride | HCID 23073545 | — |
| 反応物 | 4-Methyl-3-[4-(5-pyrimidinyl)pyridin-2-ylamino]aniline | HCID 23145962 | — |
| 生成物 | 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(5-pyrimidinyl)pyridin-2-ylamino]phenyl}benzamide | HCID 11376412 | — |
反応手順
This compound was prepared in the same manner as in Example 1, except that 4-methyl-3-[4-(5-pyrimidinyl)pyridin-2-ylamino]aniline (Reference Example 22) and 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride (Reference Example 2) were used, and that the resulting crude crystals were washed with ethyl acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728131B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b5aaea48d3164913bded93cafe769a62 |
| 出典メモ | uspto-grants-2010_06 |