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4-(Methylsulfonyl)aniline → N-(4-methylsulfonylphenyl)-2-[[2-[(4-methylsulfonylphenyl)carbamoyl]phenyl]disulfanyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Methylsulfonyl)aniline | HCID 79617 | — |
| 反応物 | 2,2'-Dithiodibenzoyl chloride | HCID 88164 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(4-methylsulfonylphenyl)-2-[[2-[(4-methylsulfonylphenyl)carbamoyl]phenyl]disulfanyl]benzamide | HCID 465351 | 56% |
反応手順
This compound was prepared according to the general method of Example 77 using 2,2'-dithiobisbenzoyl chloride (2.00 g, 5.83 mmol) in 50 mL of dichloromethane and 4-aminophenyl methyl sulfone (2.00 g, 11.7 mmol) in 16 mL of pyridine. The crude product was recrystallized from acetonitrile-DMF to yield 2.0 g of the title compound, mp 236°-238° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05668291 |
| 出典データセット | uspto-grants-1997_09 |
| ORD ID | ord-1f64bf10027a4326bb1b74ccffae1778 |
| 出典メモ | uspto-grants-1997_09 |