化工社化工社 化学情報印刷レポート · 研究参考用
Water → 6-Bromoindole-3-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 6-Bromoindole | HCID 676493 | — |
| 生成物 | 6-Bromoindole-3-carbaldehyde | HCID 2794830 | — |
反応手順
POCl3 (980 mg, 6.4 mmol) was added dropwise to DMF (3 mL) cooled in an ice bath. The mixture was stirred at 0° C. for 30 min before a solution of 6-bromo-1H-indole (1.0 g, 5.1 mmol) in DMF (7 mL) was slowly added at 0° C. The mixture was stirred at room temperature for 3 h before being poured into water and neutralized with 1N NaOH. The crude product was collected by filtration and used in next step without further purification. LCMS (m/z): 224.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08906900B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-b11a318bb24540bbb61be046c7947240 |
| 出典メモ | uspto-grants-2014_12 |