Hydrochloric Acid → Methyl (2E)-3-(3-nitrophenyl)-2-propenoate

HRID 1399938

反応式

HRID 1399938 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O)([O-:3])=[O:2].[CH3:12][O:13][C:14](=[O:22])[CH2:15]P(OC)(OC)=O.C[O-].[Na+].Cl>CN(C=O)C>[N+:1]([C:4]1[CH:5]=[C:6](/[CH:7]=[CH:15]/[C:14]([O:13][CH3:12])=[O:22])[CH:9]=[CH:10][CH:11]=1)([O-:3])=[O:2]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 74493-NitrobenzaldehydeHCID 80029Trimethyl phosphonoacetateHCID 10942334Sodium Methoxide

生成物 1

HCID 5354136Methyl (2E)-3-(3-nitrophenyl)-2-propenoate収率 98%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 3-nitro-benzaldehyde (15 g, 0.1 mol), (dimethoxy-phosphoryl)-acetic acid methyl ester (27 g, 0.148 mol) in DMF (100 ml) was added NaOMe (10.7 g 0.198 mol). The reaction was monitored by TLC. After reaction was completed, the reaction mixture was adjusted to pH=1 with aqueous HCl solution and evaporated. The resulting solid was washed with water to afford (E)-methyl 3-(3-nitrophenyl)acrylate as a yellow solid (20.14 g, 98%).

後処理

  1. customAfter reaction
  2. customevaporated
  3. washThe resulting solid was washed with water

出典と根拠

ORDレコード
ord-21764d9679824589a2b348fab79c75d6
出典データセット
uspto-grants-2014_12
特許番号
US08906909B2

関連ノート

読み込み中…