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Sodium Hydroxide → 6-(4-chloro-2-pyridinyl)-2-pyridin-2-yl-1H-pyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Pyridine-2-carboximidamide hydrochloride | HCID 12403615 | — |
| 反応物 | 3-(4-Chloropyrid-2-yl)-3-oxopropionic acid ethyl ester | HCID 53404617 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-(4-chloro-2-pyridinyl)-2-pyridin-2-yl-1H-pyrimidin-4-one | HCID 178515630 | — |
反応手順
13.15 g (58 mmol) of 3-(4-chloropyrid-2-yl)-3-oxopropionic acid ethyl ester are dissolved in 400 ml of ethanol, and 9.10 g (58 mmol) of 2-amidinopyridine hydrochloride are added. After the addition of 14.44 ml of 4N sodium hydroxide solution, refluxing is carried out for 7 hours. The mixture is cooled and concentrated to a fifth of its original volume. The crude product is filtered off and recrystallised from methanol, yielding 6-(4-chloropyrid-2-yl)-2-pyrid-2-yl-pyrimidin-4-ol in the form of beige needles.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07612010B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-d9301c198d864dcfa44e24684afd95e0 |
| 出典メモ | uspto-grants-2009_11 |