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Ammonium Chloride → 4-Chloropyridine-2-carboximidamide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4-Chloro-2-pyridinecarbonitrile | HCID 693342 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-Chloropyridine-2-carboximidamide hydrochloride | HCID 21882000 | — |
反応手順
6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07612010B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-240063da68164b27b7977e65dd3e8129 |
| 出典メモ | uspto-grants-2009_11 |