化工社化工社 化学情報印刷レポート · 研究参考用
p-Toluenesulfonic acid → Acetic acid, (dimethoxyphosphinyl)hydroxy-, (4-nitrophenyl)methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | (4-Nitrophenyl)methyl oxoacetate | HCID 12544839 | — |
| 反応物 | Dimethylphosphite | HCID 21884954 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Acetic acid, (dimethoxyphosphinyl)hydroxy-, (4-nitrophenyl)methyl ester | HCID 10064522 | — |
反応手順
To a mixture of 4.32 g of p-nitrobenzyl glyoxalate and 2.0 ml of dimethylphosphite in 25 ml of benzene is added a catalytic amount of p-toluenesulfonic acid. The reaction is heated at reflux temperature for 1.5 hours. The formed water is removed using a Dean-Stark trap. After cooling, the solvent is removed in vacuo and the resulting crystals are slurried in ethyl acetate and collected to give 3.48 g of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05602118 |
| 出典データセット | uspto-grants-1997_02 |
| ORD ID | ord-410c7e0886004c46b86f1c1c68aec268 |
| 出典メモ | uspto-grants-1997_02 |