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4-Chloro-6,7,8-trimethoxyquinazoline → HCID 22923429、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-6,7,8-trimethoxyquinazoline | HCID 100686 | — |
| 反応物 | 1,2,3,4-Tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromide | HCID 21851222 | — |
| 生成物 | HCID 22923429 | HCID 22923429 | 25% |
反応手順
The procedure similar to that described in Example 57 was repeated, except that 1.06 g (3.0 mmol) of 1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromide (Compound v) obtained in Example 41 was used and 4-chloro-6,7,8-trimethoxyquinazoline was used in place of 4-chloro-6,7-dimethoxyquinazoline. As a result, 365.1 mg (yield: 25%) of Compound 86 was obtained as white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05605900 |
| 出典データセット | uspto-grants-1997_02 |
| ORD ID | ord-1c08b2c553af49e19c1eefe528f3a07c |
| 出典メモ | uspto-grants-1997_02 |