Isopropanol → 4-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether

HRID 1459837

反応式

HRID 1459837 の反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:26]2[CH:31]=[CH:30]C(OC)=CC=2)=[CH:21][CH:20]=1.C([OH:37])(C)C>>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([O:25][CH2:26][CH:31]([OH:37])[CH2:30][N:12]2[CH2:11][CH2:10][CH:9]([C:6]3[C:5]4[CH:15]=[CH:16][C:2]([F:1])=[CH:3][C:4]=4[O:8][N:7]=3)[CH2:14][CH2:13]2)=[CH:23][CH:24]=1

参加物

4

反応物 3

HCID 3776IsopropanolHCID 74254Benzene, 1,1'-oxybis[4-methoxy-HCID 8494213-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole

生成物 1

HCID 184672574-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether

実験手順

A mixture of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (4.4 g, 20 mmol) and 2,3-epoxypropyl]-4-methoxyphenyl ether (3.7 g, 20.5 mmol) in isopropyl alcohol (80 ml) was heated to reflux for 2 hours. The mixture was cooled and the crystals were collected to yield 6.81 g (85%), m.p.=134°-135° C.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 2 hours
  3. temperatureThe mixture was cooled
  4. customthe crystals were collected
  5. customto yield 6.81 g (85%), m.p.=134°-135° C.

出典と根拠

ORDレコード
ord-b454c96ec5a24f6a9a7d7e69581668aa
出典データセット
uspto-grants-1998_12
特許番号
US05854243

関連ノート

読み込み中…