Phosphoric Acid → HCID 2802466、化合物

HRID 1462947

反応式

HRID 1462947 の反応式
[OH:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[C:4](=[O:14])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.P(=O)(O)(O)O>COCCO.O>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]([CH:6]2[CH2:5][C:4](=[O:14])[C:3]3[C:2](=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:1]2)=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 1004Phosphoric AcidHCID 6172491-(2-Hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one

生成物 1

HCID 2802466HCID 2802466、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 80192-Methoxyethanol溶媒

実験手順

The 2'-Hydroxy-4-methylchalcone of Example 13 (7.3 g.) was boiled under reflux with a solution of 85% phosphoric acid (22 ml.) in 2-methoxyethanol (219 ml.) for 8 hrs. The reaction mixture was diluted with water (1 liter) and the oily precipitate extracted into dichloromethane (300 ml.). The organic extract was separated and washed with water and saturated sodium bicarbonate solution. Filtration and evaporation gave a residue of 4'-methylflavanone contaminated with the starting chalcone.

後処理

  1. extractionthe oily precipitate extracted into dichloromethane (300 ml.)
  2. extractionThe organic extract
  3. customwas separated
  4. washwashed with water and saturated sodium bicarbonate solution
  5. filtrationFiltration and evaporation

出典と根拠

ORDレコード
ord-384e663e01314cf0b77e10d0f218e8a6
出典データセット
uspto-grants-1984_07
特許番号
US04461907

関連ノート

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