Ethyl 2-chloroacetoacetate → Ethyl 2-(2,4-dichlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

HRID 1498932

反応式

HRID 1498932 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[S:5].Cl[CH:13]([C:19]([CH3:21])=O)[C:14]([O:16][CH2:17][CH3:18])=[O:15]>C(O)C>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]1[S:5][C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:19]([CH3:21])[N:6]=1

参加物

4

反応物 2

HCID 11858Ethyl 2-chloroacetoacetateHCID 27348222,4-Dichlorobenzenecarbothioamide

生成物 1

HCID 58657933Ethyl 2-(2,4-dichlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate収率 64%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (10 ml), 2,4-dichlorothiobenzamide (378 mg) was dissolved, and ethyl 2-chloroacetoacetate (302 mg) was added thereto. The mixture was heated under reflux for 25 hours. After the mixture was allowed to cool, the precipitated crystal was separated by filtration, washed with water, and dried to give ethyl 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylate (368 mg, 64%).

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 25 hours
  3. temperatureto cool
  4. customthe precipitated crystal was separated by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-750a4e1c9298490da065ea5e7c3488a9
出典データセット
uspto-grants-2015_12
特許番号
US09200008B2

関連ノート

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