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Hydrochloric Acid → (S)-1-(1-(2-methoxybenzyl)-1H-imidazol-2-yl)-2-phenylethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (S)-tert-butyl 1-(1-(2-methoxybenzyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate | HCID 90281194 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (S)-1-(1-(2-methoxybenzyl)-1H-imidazol-2-yl)-2-phenylethanamine | HCID 90281302 | — |
反応手順
(S)-tert-butyl 1-(1-(2-methoxybenzyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate was dissolved in DCM and treated with 4 N HCl in dioxanes. The reaction was stirred for 3 hr. Solvents were removed in vacuo to provide the desired product. MS (m/z) 308.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09220710B2 |
| 出典データセット | uspto-grants-2015_12 |
| ORD ID | ord-54727a47348e492bb24cb0300b167e44 |
| 出典メモ | uspto-grants-2015_12 |