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Benzyl Bromide → 1-Benzyl-tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Dimiracetam | HCID 65955 | — |
| 反応物 | 2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amine | HCID 3513851 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-Benzyl-tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione | HCID 11264715 | 87% |
反応手順
A solution of tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione (0.5 g, 3.5 mmol, prepared as described in J. Med. Chem. 36, 4214, 1994), BEMP (2 ml, 7 mmol) and benzylbromide (0.6 ml, 5 mmol) in CH3CN (20 ml) was refluxed for 1 hour. The reaction mixture was concentrated to dryness; the residue was then re-dissolved in ethyl acetate and washed with a saturated solution of NaCl, dried over Na2SO4, filtered and evaporated under vacuum. The residue was purified by flash chromatography over silica gel (CH2Cl2/MeOH/NH4OH 95/5/0.5) to afford 0.7 g of the title compound as yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732473B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-63d0142ac98d4c76927d6b43eec7f446 |
| 出典メモ | uspto-grants-2010_06 |