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HRID 1511368作成日：2026年10月23日
(Trifluoromethyl)trimethylsilane → (R)-N-((S)-1-(4-bromo-2-chlorophenyl)-2,2,2-trifluoroethyl)-2-methylpropane-2-sulfinamide
https://huagongshe.com/ja/reaction/1511368
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| 反応物 | (NZ,R)-N-[(4-bromo-2-chlorophenyl)methylidene]-2-methylpropane-2-sulfinamide | HCID 57691068 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (R)-N-((S)-1-(4-bromo-2-chlorophenyl)-2,2,2-trifluoroethyl)-2-methylpropane-2-sulfinamide | HCID 57691004 | — |
反応手順
To a stirring solution of (R,Z)—N-(4-bromo-2-chlorobenzylidene)-2-methylpropane-2-sulfinamide (1370 mg, 4246 μmol) and (trifluoromethyl)trimethylsilane (943 μl, 6369 μmol) in DMF (5 mL) was added 1,3-bis(1-adamantyl)imidazol-2-ylidene (143 mg, 425 μmol). Reaction stirred at 35° C. for 18 h then quenched with sat NH4Cl (10 mL). Reaction partitioned between EtOAc (40 mL) and 5% NaHCO3 (10 mL). Organic dried over MgSO4, concentrated to and oil from toluene, then purified on silica (80 g) eluting with 20>30% EtOAc/Hex. Product isolated as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08212041B2 |
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| 出典データセット | uspto-grants-2012_07 |
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| ORD ID | ord-0e586812655441979c84f2328da396a2 |
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| 出典メモ | uspto-grants-2012_07 |
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