化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → METHYL 3-(HYDROXYMETHYL)-5-NITROBENZOATE
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methyl 3-(chlorocarbonyl)-5-nitrobenzoate | HCID 74774 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | METHYL 3-(HYDROXYMETHYL)-5-NITROBENZOATE | HCID 10703703 | — |
反応手順
A stirred solution of the product from step (i) (46.54 g) and sodium borohydride (13.01 g) in 1,4-dioxane (200 ml) was heated at reflux for 17 hours. The mixture was cooled and treated with triethylamine (27.9 ml), poured onto ice-water and extracted with ethyl acetate. The combined extracts were dried (MgSO4) and evaporated. The product was recrystallised from isohexane. Yield 19.38 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06200981B1 |
| 出典データセット | uspto-grants-2001_03 |
| ORD ID | ord-8ae2dc45fa73405cbbda1d2570d69ebf |
| 出典メモ | uspto-grants-2001_03 |