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Hydrochloric Acid → H-Ala(3-pyridyl)-OMe.2HCl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diethyl acetamido[(pyridin-3-yl)methyl]propanedioate | HCID 13817914 | — |
| 生成物 | H-Ala(3-pyridyl)-OMe.2HCl | HCID 46862166 | 100% |
反応手順
Diethyl 2-(3-pyridylmethyl)-2-acetamidomalonate was dissolved in 6N HCl (30 mL) and heated to reflux for 19 hours whereupon it was cooled to room temperature and the HCl solution was removed by evaporation in vacuo. The intermediate amino acid dihydrochloride salt was taken up into MeOH (30 mL) saturated with HCl gas and stirred for 3.5 hours. The MeOH/HCl was removed by evaporation in vacuo to give 3-(3-pyridyl)alanine methyl ester dihydrochloride (2.235 g, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06207710B1 |
| 出典データセット | uspto-grants-2001_03 |
| ORD ID | ord-5b5d7a85623f46b38fe400400373da8b |
| 出典メモ | uspto-grants-2001_03 |