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HRID 15554作成日：2026年10月24日
Potassium Carbonate → {5-[[2-(4-Chloro-phenoxy)-ethyl]-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester
https://huagongshe.com/ja/reaction/15554
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(2-Bromoethoxy)-4-chlorobenzene | HCID 74854 | — |
| 反応物 | [5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester | HCID 67201670 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | {5-[[2-(4-Chloro-phenoxy)-ethyl]-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester | HCID 67199976 | — |
反応手順
4-Chlorophenyl 2-bromoethyl ether (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07732618B2 |
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| 出典データセット | uspto-grants-2010_06 |
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| ORD ID | ord-f2942afb7aa342c8bf408c4be920b261 |
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| 出典メモ | uspto-grants-2010_06 |
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