化工社化工社 化学情報印刷レポート · 研究参考用
Isobutyryl chloride → [5-(Benzyl-isobutyryl-amino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutyryl chloride | HCID 62325 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | (5-Benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester | HCID 67200053 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | [5-(Benzyl-isobutyryl-amino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester | HCID 67200174 | — |
反応手順
Isobutyryl chloride (38 μL, 0.36 mmol) was added to a solution of (5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (45 mg, 0.12 mmol), DIEA (41 μL, 0.24 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2 (1 mL), and stirred overnight at room temperature. The reaction solution was diluted with aqueous HCl (1.0 M) and filtered through an Extrelut column. The Extrelut column was washed with CH2Cl2, and the filtrate was concentrated to afford the subtitle compound that was used without further purification. MS calculated for C27H35N3O3+H: 450, observed: 450.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732618B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6214346e4a9842cb87e4219a874af32a |
| 出典メモ | uspto-grants-2010_06 |