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Ethanol → 2,3,5,6-Tetrafluorobenzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2,3,5,6-Tetrafluorobenzoic Acid | HCID 567533 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2,3,5,6-Tetrafluorobenzyl alcohol | HCID 2734029 | 46.7% |
反応手順
Lithium aluminium hydride (4.6 g) was added in small portions to a stirred solution of 2,3,5,6-tetrafluorobenzoic acid (30.0 g) in dry ether (600 ml) at the ambient temperature, and stirring continued for a period of 3 hours. After decomposition of the excess lithium aluminium hydride with ethyl alcohol, water was added in excess and the ethereal phase separated, washed with water, and concentrated to yield crude 2,3,5,6-tetrafluorobenzyl alcohol (13.0 g) as a colourless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04551546 |
| 出典データセット | uspto-grants-1985_11 |
| ORD ID | ord-c23323c0fa614cb4bbdac1a29995d20e |
| 出典メモ | uspto-grants-1985_11 |