Hydrochloric Acid → 2,3,3,3-Tetrafluoro-2-methoxypropanoic acid

HRID 1591020

反応式

HRID 1591020 の反応式
[C:1]([C:5]([C:9]([O:11]C)=[O:10])([O:7][CH3:8])[F:6])([F:4])([F:3])[F:2].[OH-].[K+].Cl>O>[CH3:8][O:7][C:5]([F:6])([C:1]([F:2])([F:3])[F:4])[C:9]([OH:11])=[O:10]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2775434Methyl 2-methoxytetrafluoropropionate

生成物 1

HCID 111058852,3,3,3-Tetrafluoro-2-methoxypropanoic acid収率 80%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of methyl 2-methoxytetrafluoropropionate formed in Example 1 (41.9 g), water (500 ml) and potassium hydroxide (56 g) was refluxed for 3 hours. The reaction mixture was acidified with 100 ml of equal parts hydrochloric acid and water and extracted with three 200 ml portions of ether. The combined ether extracts were dried over sodium sulfate. After evaporation of the ether, fractional distillation gave 2-methoxytetrafluoropropionic acid (31.0 g. 80%), b.p. 67°-68° (12 mm Hg).

後処理

  1. temperaturewas refluxed for 3 hours
  2. extractionextracted with three 200 ml portions of ether
  3. dry with materialThe combined ether extracts were dried over sodium sulfate
  4. customAfter evaporation of the ether, fractional distillation

出典と根拠

ORDレコード
ord-f764b3baaae641feacb45823580c77e4
出典データセット
uspto-grants-1993_04
特許番号
US05205914

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