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Bromine → 1-(4-Pentylphenyl)-2-(2,6-difluoropyridine-3-yl)acetylene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2,6-Difluoropyridine | HCID 73934 | — |
| 反応物 | Lithium diisopropylamide | HCID 2724682 | — |
| 反応物 | 3-Bromo-2,6-difluoropyridine | HCID 19765739 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 生成物 | 1-(4-Pentylphenyl)-2-(2,6-difluoropyridine-3-yl)acetylene | HCID 19765761 | — |
反応手順
0,2 mM of Pd(Ph3P)2Cl2 and 0,1 mM of CuJ are added to a mixture of 0,01 M of 3-bromo-2,6-difluoropyridine (preparation: 2,6-difluoropyridine is reacted with lithiumdiisopropylamide (LDA) as described in example 3a, then Br2 is added at -60° to -70°. The mixture is allowed to warm up to room temperature and worked up, the product is purified by distillation), 0,01 M of 4-pentylphenylacetylene and 200 ml of triethylamine. The mixture is stirred for 8 hours at room temperature; after customary work-up and purification by crystallization and chromatography 1-(4-pentylphenyl)-2-(2,6-difluoropyridine-3-yl)acetylene is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05205962 |
| 出典データセット | uspto-grants-1993_04 |
| ORD ID | ord-985d2f9b05bf4439be574206950131d3 |
| 出典メモ | uspto-grants-1993_04 |