6-Chlorotryptophan → 6-Chloro-N-formyl-L-tryptophan

HRID 1658536

反応式

HRID 1658536 の反応式
[CH:1]1[C:6]([Cl:7])=[CH:5][C:4]2[NH:8][CH:9]=[C:10]([CH2:11][CH:12]([NH2:16])[C:13]([OH:15])=[O:14])[C:3]=2[CH:2]=1.[CH:17](OC(=O)C)=[O:18]>>[CH:17]([NH:16][C@H:12]([C:13]([OH:15])=[O:14])[CH2:11][C:10]1[C:3]2[C:4](=[CH:5][C:6]([Cl:7])=[CH:1][CH:2]=2)[NH:8][CH:9]=1)=[O:18]

参加物

3

反応物 2

HCID 652596-ChlorotryptophanHCID 75269Acetic-formic anhydride

生成物 1

HCID 227910706-Chloro-N-formyl-L-tryptophan

実験手順

15 g(628 mM) of dl-6-chlorotryptophan was treated with 15 ml of acetic-formic anhydride. An exothermic reaction ensued, accompanied by solidification of the reaction slurry. Excess solvents were distilled off under vacuum and the resultant solids, after first leaching with dilute acid, were recrystallized from ethyl acetate to yield 12.45 g, 74%, of product, m.p, 181°-3° dec.

後処理

  1. customAn exothermic reaction
  2. distillationExcess solvents were distilled off under vacuum
  3. additionthe resultant solids, after first leaching with dilute acid
  4. customwere recrystallized from ethyl acetate
  5. customto yield 12.45 g, 74%

出典と根拠

ORDレコード
ord-3b911ac8906347b0b5e4aab831a6226e
出典データセット
uspto-grants-1976_06
特許番号
US03965121

関連ノート

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