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2,6-Di-tert-butyl-4-(chloromethyl)phenol → (3,5-Di-tert-butyl-4-hydroxy-benzyl)-cyclohexyl-phosphinic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Di-tert-butyl-4-(chloromethyl)phenol | HCID 12378601 | — |
| 反応物 | Dimethylcyclohexylphosphonite | HCID 21678155 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (3,5-Di-tert-butyl-4-hydroxy-benzyl)-cyclohexyl-phosphinic acid methyl ester | HCID 57909097 | 51.2% |
反応手順
A mixture of 10.47 grams (59 mmol) of dimethylcyclohexylphosphonite with 15.14 grams (59 mmol) of 3,5-di-tert-butyl-4-hydroxybenzyl chloride (CAS REG # 955-01-1) in 45 mL of toluene is refluxed for 2 hours and is cooled. The resultant precipitated crystals are collected by filtration, washed with toluene, then hexane and are dried under vacuum to obtain 11.5 grams (51% yield) of (3,5-di-tert-butyl-4-hydroxy-benzyl)-cyclohexyl-phosphinic acid methyl ester as a white solid mp 149-150° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030435B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-e40d7e2e6f504d5cb0f0acf81a2d09f5 |
| 出典メモ | uspto-grants-2011_10 |