関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Bromoanisole | HCID 7730 | — |
| 反応物 | Methyl 2-amino-2-methylpropanoate | HCID 4186341 | — |
| 試薬 | Sodium 2-methylbutan-2-olate | HCID 2733478 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 触媒 | Bis(adamantan-1-yl)(butyl)phosphane | HCID 11371790 | — |
| 溶媒 | (Trifluoromethyl)benzene | HCID 7368 | — |
| 生成物 | Methyl 2-(4-methoxyanilino)-2-methylpropanoate | HCID 60992690 | 0% |
反応手順
1-bromo-4-methoxybenzene (0.060 mL, 0.47 mmol), methyl 2-amino-2-methylpropanoate (0.05 g, 0.43 mmol), sodium 2-methylbutan-2-olate (0.052 g, 0.47 mmol), diacetoxypalladium (2.68 mg, 0.01 mmol) and methyl 2-(4-methoxyphenylamino)-2-methylpropanoate (0.00 µg) was added to a microwave vial. (TRIFLUOROMETHYL)-BENZENE (0.5 mL) was used as solvent (1-1.2 mL/mmol amine). The mixture was heated in microwave at 180° for 60min. No conversion of startingmaterial was observed.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-6a2eab081b6a474896fa34b3a81f3801 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
