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2-Methylsulfonylbenzaldehyde → 6-[4-[(2-Methylsulfonylphenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylsulfonylbenzaldehyde | HCID 220377 | — |
| 反応物 | 6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine | HCID 1476862 | — |
| 生成物 | 6-[4-[(2-Methylsulfonylphenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 67339638 | — |
反応手順
Reductive amination of 6-(piperazin-1-yl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine with 2-methylsulfonylbenzaldehyde was carried out according to General Synthetic Method 5. The crude product was purified by hplc using a Waters XBridge Prep C18 OBD column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 1% aqueous ammonia) and acetonitrile as eluents to give 6-[4-[(2-methylsulfonylphenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08003649B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-256cb2c2303946e38c8f1f3ef85cb62f |
| 出典メモ | uspto-grants-2011_08 |