関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Chlorotoluene | HCID 7810 | — |
| 反応物 | Methyl 2-amino-2-methylpropanoate | HCID 4186341 | — |
| 試薬 | Sodium t-butoxide | HCID 23676156 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 触媒 | Bis(adamantan-1-yl)(butyl)phosphane | HCID 11371790 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Methyl 2-methyl-2-[(4-methylphenyl)amino]propanoate | HCID 60992031 | 0% |
反応手順
A flask was loaded with diacetoxypalladium (6.39 mg, 0.03 mmol), BUTYLDI-1-ADAMANTYLPHOSPHINE (0.020 g, 0.06 mmol), sodium 2-methylpropan-2-olate (0.164 g, 1.71 mmol) and methyl 2-amino-2-methylpropanoate (0.2 g, 1.71 mmol). The flask was evacuated and backfilled and toluene (5ml) and 1-chloro-4-methylbenzene (0.168 ml, 1.42 mmol) was added.The mixture was stirred for 20h at 120°. No conversion of startingmaterial was observed.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-adf0259dd1b4403cabef49044d700c84 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
