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1-(Trimethylsilyl)prop-1-yne → 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-trimethylsilanyl-1H-[1,2,3]triazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Trimethylsilyl)prop-1-yne | HCID 80363 | — |
| 反応物 | 8-Azido-1,4-dioxaspiro[4.5]decane | HCID 57424094 | — |
| 生成物 | 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-trimethylsilanyl-1H-[1,2,3]triazole | HCID 57795425 | 105% |
反応手順
A mixture of 8-Azido-1,4-dioxa-spiro[4.5]decane (1.00 g, 5.43 mmol) and 1-(trimethylsilyl)propyne (3.76 mL, 27.1 mmol) was submitted to microwave at 120° C. for 2 h. The mixture was concentrated under vacuum to remove the excess of 1-(trimethylsilyl)propyne and crude 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-trimethylsilanyl-1H-[1,2,3]triazole (1.6 g, 105%) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08158675B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-3f4a0932261f4295845f2833878ea275 |
| 出典メモ | uspto-grants-2012_04 |