化工社化工社 化学情報印刷レポート · 研究参考用
Hydrogen iodide → 6-hydroxy-1H-indazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen iodide | HCID 24841 | — |
| 反応物 | 6-Methoxy-1H-indazole | HCID 12639202 | — |
| 生成物 | 6-hydroxy-1H-indazole | HCID 135483987 | 86% |
反応手順
A mixture of 6-methoxy-1H-indazole (560 mg, 3.8 mmol) and HI (2.4 mL 48%) was heated to reflux for 4 h. The mixture was extracted with CH2Cl2. The combined organic layers were washed with water, brine, concentrated in vacuo, and purified by column chromatography (CH2Cl2/MeOH=60/1) to give 1H-indazol-6-ol (intermediate 43) (436 mg, 86%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09156822B2 |
| 出典データセット | uspto-grants-2015_10 |
| ORD ID | ord-bce95d5fbb24486a961c4d7923b9ac97 |
| 出典メモ | uspto-grants-2015_10 |