化工社化工社 化学情報印刷レポート · 研究参考用
4-Fluorophenol → 5,7-Bis(difluoromethyl)-2-[3-(4-fluorophenoxy)propyl]-[1,2,4]triazolo[1,5-a]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorophenol | HCID 9732 | — |
| 反応物 | 1,1,5,5-Tetrafluoro-2,4-pentanedione | HCID 12640721 | — |
| 反応物 | HCID 178508402 | HCID 178508402 | — |
| 反応物 | 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine | HCID 178508403 | — |
| 生成物 | 5,7-Bis(difluoromethyl)-2-[3-(4-fluorophenoxy)propyl]-[1,2,4]triazolo[1,5-a]pyrimidine | HCID 86719329 | 72% |
| 生成物 | 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine | HCID 178508403 | — |
反応手順
The title compound was prepared according to the experimentals described for Example 22 above from 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine and 1,1,5,5-tetrafluoropentane-2,4-dione in 72% yield. The reagent 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine was prepared by a similar procedure for the synthesis of 3-[3-(4-chlorophenoxy)propyl]-1H-1,2,4-triazol-5-amine in Example 22 above, beginning from 4-fluorophenol instead of 4-chlorophenol. 1H NMR (DMSO-d6, 400 MHz) δ ppm: 7.83 (s, 1H), 7.63 (t, 1H), 7.18 (t, 1H), 7.09 (m, 2H), 6.95 (m, 2H), 4.08 (t, 2H), 3.11 (t, 2H), 2.24 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09163027B2 |
| 出典データセット | uspto-grants-2015_10 |
| ORD ID | ord-b836ab28fa234825b8fabc591f498313 |
| 出典メモ | uspto-grants-2015_10 |